Gut feelings about smoking and coffee in Parkinson's Disease
Identifieur interne : 000968 ( Main/Exploration ); précédent : 000967; suivant : 000969Gut feelings about smoking and coffee in Parkinson's Disease
Auteurs : Pascal Derkinderen [France] ; Kathleen M. Shannon [États-Unis] ; Patrik Brundin [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Coffee.
- epidemiology : Parkinson Disease, Smoking.
- etiology : Parkinson Disease.
- innervation : Gastrointestinal Tract.
- microbiology : Gastrointestinal Tract.
- psychology : Parkinson Disease.
- Humans, Microbiota, Risk Factors.
Abstract
Strong epidemiological evidence suggests that smokers and coffee drinkers have a lower risk of Parkinson’s disease (PD). The explanation for this finding is still unknown and the discussion has focused on two main hypotheses. The first suggests that PD patients have premorbid personality traits associated with dislike for coffee-drinking and smoking. The second posits that caffeine and nicotine are neuroprotective. We propose an alternative third hypothesis in which both cigarette and coffee consumption change the composition of the microbiota in the gut in a way that mitigates intestinal inflammation. This, in turn, would lead to less misfolding of the protein alpha-synuclein in enteric nerves, reducing the risk of PD by minimizing propagation of the protein aggregates to the central nervous system where they otherwise can induce neurodegeneration.
Url:
DOI: 10.1002/mds.25882
PubMed: 24753353
PubMed Central: 4107006
Affiliations:
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Le document en format XML
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This, in turn, would lead to less misfolding of the protein alpha-synuclein in enteric nerves, reducing the risk of PD by minimizing propagation of the protein aggregates to the central nervous system where they otherwise can induce neurodegeneration.</p></div></front></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country><region><li>Illinois</li><li>Michigan</li><li>Pays de la Loire</li></region></list><tree><country name="France"><region name="Pays de la Loire"><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name></region><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name></country><country name="États-Unis"><region name="Illinois"><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M" last="Shannon">Kathleen M. Shannon</name></region><name sortKey="Brundin, Patrik" sort="Brundin, Patrik" uniqKey="Brundin P" first="Patrik" last="Brundin">Patrik Brundin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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